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Association between ABHD1 and DOK6 polymorphisms and susceptibility to Hirschsprung disease in Southern Chinese children.
Lan C, Wu Y, Wang N, Luo Y, Zhao J, Zheng Y, Zhang Y, Huang L, Zhu Y, Lu L, Zhong W, Zeng J, Xia H. Lan C, et al. J Cell Mol Med. 2021 Oct;25(20):9609-9616. doi: 10.1111/jcmm.16905. Epub 2021 Sep 20. J Cell Mol Med. 2021. PMID: 34545688 Free PMC article.
The alpha/beta-hydratase domain 1 (ABHD1) interferes with the proliferation and migration of intestinal stem cells. Docking protein 6 (DOK6) is involved in neurodevelopment through RET signalling pathway. ...This study verified two susceptible variations of HSCR on …
The alpha/beta-hydratase domain 1 (ABHD1) interferes with the proliferation and migration of intestinal stem cells. Docking protein 6 (DO
Docking protein 6 (DOK6) selectively docks the neurotrophic signaling transduction to restrain peripheral neuropathy.
Guo Y, Xiang P, Sun X, Liu W, Zhou J, Yin B, Hou L, Qiang B, Li H, Shu P, Peng X. Guo Y, et al. Signal Transduct Target Ther. 2024 Feb 14;9(1):32. doi: 10.1038/s41392-024-01742-2. Signal Transduct Target Ther. 2024. PMID: 38351062 Free PMC article.
Furthermore, Dok6 is highly expressed in peripheral neurons but not in Schwann cells, and genetic deletion of Dok6 in peripheral neurons led to typical peripheral myelin outfolding, axon destruction, and hindered retrograde axonal transport. Specifically, DOK6
Furthermore, Dok6 is highly expressed in peripheral neurons but not in Schwann cells, and genetic deletion of Dok6 in peripher …
Analysis of DOK-6 function in downstream signaling of RET in human neuroblastoma cells.
Kurotsuchi A, Murakumo Y, Jijiwa M, Kurokawa K, Itoh Y, Kodama Y, Kato T, Enomoto A, Asai N, Terasaki H, Takahashi M. Kurotsuchi A, et al. Cancer Sci. 2010 May;101(5):1147-55. doi: 10.1111/j.1349-7006.2010.01520.x. Epub 2010 Feb 3. Cancer Sci. 2010. PMID: 20210798 Free article.
The binding affinity of the DOK-6 phosphotyrosine-binding (PTB) domain to RET was much lower than that of the DOK-1, DOK-4, and SHC PTB domains to RET. These findings indicate that DOK-6 is involved in RET signaling with less influence when compared with DOK- …
The binding affinity of the DOK-6 phosphotyrosine-binding (PTB) domain to RET was much lower than that of the DOK-1, DOK-4, and SHC P …
Dok-6, a Novel p62 Dok family member, promotes Ret-mediated neurite outgrowth.
Crowder RJ, Enomoto H, Yang M, Johnson EM Jr, Milbrandt J. Crowder RJ, et al. J Biol Chem. 2004 Oct 1;279(40):42072-81. doi: 10.1074/jbc.M403726200. Epub 2004 Jul 30. J Biol Chem. 2004. PMID: 15286081 Free article.
Pull-down assays using the Dok-6 phosphotyrosine binding (PTB) domain and GDNF-activated Ret indicate that Dok-6 binds to the phosphorylated Ret Tyr(1062) residue. Moreover, ligand activation of Ret resulted in phosphorylation of tyrosine residue(s) located w …
Pull-down assays using the Dok-6 phosphotyrosine binding (PTB) domain and GDNF-activated Ret indicate that Dok-6 binds to the phospho …